REJURAN represents a revolutionary approach to skin rejuvenation—working at the cellular level to repair, restore, and revitalize your skin’s natural vitality from within. Unlike treatments that simply fill wrinkles or temporarily plump the skin, REJURAN harnesses the restorative power of polynucleotides (PN) derived from salmon DNA to stimulate your body’s own healing mechanisms, producing gradual improvements in texture, elasticity, and overall skin health that look and feel authentically natural.

Originally developed in South Korea—where it earned the nickname “skin healer”—REJURAN has become one of the most sought-after advanced skin treatments worldwide, praised for its ability to address fine lines, scarring, enlarged pores, and environmentally damaged skin without the risks or downtime of more invasive procedures.

What Is REJURAN Polynucleotide Therapy?

REJURAN is a skin booster treatment that utilizes purified polynucleotides—short fragments of DNA extracted from salmon—to trigger skin renewal at the deepest cellular level. These polynucleotides share a remarkable 97% structural similarity with human DNA, making them highly biocompatible and well-tolerated by virtually all skin types.

When delivered into the dermis, polynucleotides act as biological catalysts that activate fibroblasts—the cells responsible for producing collagen and elastin. This stimulation enhances your skin’s natural repair processes, promoting new cell growth, strengthening the extracellular matrix, and improving the skin’s ability to retain moisture. The result is healthier, more resilient skin that continues to improve over weeks and months following treatment.

How REJURAN Stimulates Collagen and Skin Repair

The science behind REJURAN is rooted in the restorative properties of polynucleotides and their ability to influence multiple aspects of skin health simultaneously. When introduced to the dermis, these DNA fragments trigger a cascade of beneficial cellular responses.

Polynucleotides stimulate fibroblast proliferation and activity, directly increasing collagen and elastin synthesis. They promote angiogenesis—the formation of new blood vessels—which improves nutrient delivery and skin tone. The treatment enhances glycosaminoglycan production, essential compounds that help skin retain moisture and maintain hydration. Additionally, polynucleotides exhibit powerful anti-inflammatory and antioxidant properties, protecting cells from free radical damage while calming irritated or sensitized skin.

This multi-pathway approach makes REJURAN exceptionally effective for comprehensive skin rejuvenation, addressing not just visible signs of aging but the underlying cellular dysfunction that causes them.

Benefits of REJURAN for Skin Texture and Elasticity

REJURAN delivers transformative benefits that extend far beyond what traditional skincare or surface-level treatments can achieve. Patients consistently report significant improvements in skin texture—smoother, more refined skin with visibly reduced pore size and improved clarity. Fine lines and expression wrinkles soften as collagen fibers become stronger and more organized.

Skin elasticity improves noticeably, with firmer, more lifted skin particularly evident in areas prone to sagging like the cheeks and jawline. Hydration levels increase as the treatment enhances the skin’s natural moisture-binding capacity, transforming dry, dull complexions into soft, dewy skin with healthy luminosity. For patients with acne scarring or post-inflammatory damage, REJURAN’s tissue remodeling properties help smooth uneven texture and improve overall skin tone.

“REJURAN exemplifies what we mean by advanced aesthetics at NexGen Health,” says Dr. James Petros. “Rather than masking imperfections or creating artificial volume, we’re helping the skin rebuild its own structure and function. Patients love that their results look natural—because they are natural. The skin is genuinely healthier, not just temporarily improved.”

REJURAN Treatment for Acne Scars and Skin Damage

One of REJURAN’s most compelling applications is its ability to improve scarring and skin damage that other treatments struggle to address. The polynucleotides’ tissue remodeling properties make it particularly effective for acne scars, promoting collagen reorganization that gradually smooths depressed or uneven skin surfaces.

For environmentally damaged skin—whether from years of sun exposure, pollution, or improper skincare—REJURAN helps restore the skin’s protective barrier function while reducing inflammation and oxidative stress. This makes it an excellent option for patients whose skin has been compromised by harsh treatments, over-exfoliation, or chronic conditions like rosacea. The treatment’s anti-inflammatory properties calm reactive skin while simultaneously strengthening its resilience against future damage.

What to Expect During Your REJURAN Session

At NexGen Health, REJURAN is applied in conjunction with microneedling to maximize absorption and results. The microneedling device creates controlled microchannels in the skin, allowing the polynucleotides to penetrate directly into the dermis where they can most effectively stimulate repair and renewal.

Your treatment begins with a thorough cleansing of the treatment area, followed by application of a topical numbing cream to ensure comfort throughout the procedure. The microneedling session with REJURAN application typically takes 45-60 minutes depending on the treatment area. Most patients describe the sensation as mild and tolerable, with minimal discomfort.

Following treatment, you may experience mild redness, slight swelling, or pinpoint marks at the treatment sites—these typically resolve within one to three days. There’s no significant downtime, and most patients return to normal activities immediately. Results develop gradually as your skin responds to the restorative signals, with initial improvements visible within two to four weeks and continued enhancement over the following months.

REJURAN Treatment Timeline and Expected Results

REJURAN’s effects unfold progressively, reflecting the treatment’s focus on genuine cellular renewal rather than temporary cosmetic changes. After your first session, subtle improvements in skin texture and hydration typically become noticeable within one to two weeks. However, the full transformation develops over a series of treatments.

For optimal results, a course of three to four treatments spaced approximately four to six weeks apart is recommended. This allows adequate time for collagen synthesis and tissue remodeling between sessions while building cumulative benefits. Following the initial treatment series, results typically last six to twelve months depending on age, skin condition, and lifestyle factors. Maintenance treatments every six to twelve months help sustain long-term improvements and continue supporting skin health.

Ideal Candidates for REJURAN Skin Rejuvenation

REJURAN is well-suited for adults seeking natural, gradual improvements in skin quality without dramatic interventions. The treatment is particularly effective for individuals experiencing early signs of aging including fine lines, loss of elasticity, and dull or dehydrated skin. Those dealing with acne scarring, enlarged pores, or uneven texture also see excellent results.

Patients in their 30s through 50s typically experience the most noticeable improvements, though mature skin can also benefit from REJURAN’s restorative properties. The treatment is especially appealing for those who value prevention—younger patients often choose REJURAN as a proactive strategy to maintain healthy, resilient skin before deeper wrinkles form.

Thanks to its exceptional biocompatibility, REJURAN is safe and effective for most skin types including sensitive or reactive skin. However, individuals with active skin infections, severe fish allergies, or certain autoimmune conditions should consult with our medical team to determine if this treatment is appropriate.

Frequently Asked Questions About REJURAN

How is REJURAN different from fillers or Botox?

REJURAN works fundamentally differently than fillers or neurotoxins. It doesn't add volume or freeze muscles—instead, it stimulates your skin's own restorative processes to produce genuine improvements in texture, elasticity, and health from within. Results look natural because they are your skin's own response to treatment.

Is REJURAN safe?

Yes. The polynucleotides in REJURAN share 97% structural similarity with human DNA, making them highly biocompatible. The treatment has been used extensively in South Korea for years and has an excellent safety profile. Side effects are typically mild and temporary, including slight redness or swelling that resolves within days.

How many treatments will I need?

Most patients achieve optimal results with three to four treatments spaced four to six weeks apart. Your treatment plan will be customized based on your skin condition and goals. Maintenance treatments every six to twelve months help sustain long-term results.

When will I see results?

Initial improvements in hydration and texture typically appear within one to two weeks after your first treatment. Results continue to develop and improve over the following weeks and months as collagen synthesis increases and tissue remodeling occurs.

Can REJURAN be combined with other treatments?

Absolutely. REJURAN pairs beautifully with other advanced treatments like Morpheus8, laser resurfacing, and peptide therapy. Combining treatments often produces synergistic results that exceed what any single therapy can achieve alone.

Is there any downtime?

Downtime is minimal. Most patients experience mild redness and possible pinpoint marks that resolve within one to three days. You can typically return to normal activities immediately, though we recommend avoiding intense exercise and direct sun exposure for 24-48 hours.

Why Choose NexGen Health for REJURAN Treatment

NexGen Health brings REJURAN into our comprehensive advanced aesthetics program, combining this polynucleotide therapy with complementary treatments and medical expertise for superior results. Our physicians understand how REJURAN integrates with other restorative protocols—from microneedling and Morpheus8 to ACORN Secretome and medical-grade skincare—allowing us to create customized treatment plans that address your unique concerns from multiple angles.

Located in San Jose and serving patients throughout Los Gatos, Cupertino, Mountain View, and Silicon Valley, we provide the physician oversight and personalized attention that this sophisticated therapy deserves.

Schedule Your REJURAN Consultation in San Jose

Ready to experience the restorative power of polynucleotide therapy? Contact NexGen Health today to schedule your consultation and discover how REJURAN can help you achieve healthier, more youthful skin naturally. Call us at +1 (408) 400-2967 or book your appointment online.